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ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Frontiers of Medicine   Pages 972-992 doi: 10.1007/s11684-023-0990-1

Abstract: Owing to the increasing incidence and prevalence of inflammatory bowel disease (IBD) worldwide, effective and safe treatments for IBD are urgently needed. Hydrogen sulfide (H2S) is an endogenous gasotransmitter and plays an important role in inflammation. To date, H2S-releasing agents are viewed as potential anti-inflammatory drugs. The slow-releasing H2S donor 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADT-OH), known as a potent therapeutic with chemopreventive and cytoprotective properties, has received attention recently. Here, we reported its anti-inflammatory effects on dextran sodium sulfate (DSS)-induced acute (7 days) and chronic (30 days) colitis. We found that ADT-OH effectively reduced the DSS-colitis clinical score and reversed the inflammation-induced shortening of colon length. Moreover, ADT-OH reduced intestinal inflammation by suppressing the nuclear factor kappa-B pathway. In vivo and in vitro results showed that ADT-OH decreased intestinal permeability by increasing the expression of zonula occludens-1 and occludin and blocking increases in myosin II regulatory light chain phosphorylation and epithelial myosin light chain kinase protein expression levels. In addition, ADT-OH restored intestinal microbiota dysbiosis characterized by the significantly increased abundance of Muribaculaceae and Alistipes and markedly decreased abundance of Helicobacter, Mucispirillum, Parasutterella, and Desulfovibrio. Transplanting ADT-OH-modulated microbiota can alleviate DSS-induced colitis and negatively regulate the expression of local and systemic proinflammatory cytokines. Collectively, ADT-OH is safe without any short-term (5 days) or long-term (30 days) toxicological adverse effects and can be used as an alternative therapeutic agent for IBD treatment.

Keywords： inflammatory bowel disease     ADT-OH     intestinal permeability     gut microbiota    

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Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Engineering doi: 10.1016/j.eng.2022.10.010

Abstract: Through the metagenomic sequencing of stool samples, we found that PTH administration restored the gutIn addition, PTH restored the gut barrier function in mice with steatohepatitis, as evidenced by reducedWe further confirmed that an intact gut microbiota is necessary for PTH to exhibit anti-steatohepatitisIn conclusion, PTH protects against steatohepatitis development by modulating the gut microbiota and

Keywords： Pien Tze Huang     Non-alcoholic steatohepatitis     Gut barrier function     Gut microbiota    

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Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 123-129 doi: 10.1007/s11684-017-0563-2

Abstract: Intestinal barrier destruction is widely observed among patients receiving liver transplant and sufferingrejection injuries because of the relationship between the intestine and the liver, both in anatomy and functionImportantly, the resulting alteration of gut microbiota aggravates graft dysfunctions during the processThis article reviews the research progress for gut microbial alterations and liver transplantation.The aim is not only to predict perioperative injuries but also to function as a method of treatment or

Keywords： gut microbial balance     liver transplantation     ischemia–reperfusion     acute rejection    

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Integrated analysis of gut microbiome and host immune responses in COVID-19

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 263-275 doi: 10.1007/s11684-022-0921-6

Abstract: Emerging evidence indicates that the gut microbiome contributes to the host immune response to infectiousHere, to explore the role of the gut microbiome in the host immune responses in COVID-19, we conductedWe found that the diversity of the gut microbiome was reduced in severe/critical COVID-19 cases comparedWe identified the abundance of some gut microbes altered post-SARS-CoV-2 infection and related to diseasea correlation map between clinical features of COVID-19 and 16 severity-related gut microbe, including

Keywords： COVID-19     SARS-COV-2     gut microbiome     immune response    

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Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: disease because of the intricate role of gut microbiota in maintaining human health and disease formationMoreover, gut microbiota is even regarded as a “metabolic organ” that play complementary roles to thatAs a result, gut microbiota have been emerging as a novel therapeutic target for NAFLD by manipulatingIn this review, we summarized the most recent advances in gut microbiota-mediated mechanisms, as wellas gut microbiota-targeted therapies on NAFLD.

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

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Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Article

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Engineering 2022, Volume 15, Issue 8,   Pages 115-125 doi: 10.1016/j.eng.2021.03.013

Abstract: As allergic disease has been associated with gut dysbiosis, we searched for a possible mechanism fromderivatives (especially valine, and IPA which is the reductive product of tryptophan) , SCFAs, and the gutmicrobiome (specifically Akkermansia and Helicobacter) may disrupt the intestinal barrierfunction by inhibiting the expression of claudin proteins and affecting the mucus layer, which further

Keywords： Metabolome     Gut microbiota     Hay fever     Allergic diseases     Intestinal barrier dysfunction    

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Adaptive tracking control for air-breathing hypersonic vehicles with state constraints Article

Gong-jun LI

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 5,   Pages 599-614 doi: 10.1631/FITEE.1500464

Abstract: velocity, the altitude, and the pitch angle), a modified backstepping design is proposed where the barrierLyapunov function is used to solve the state-constrained control problem and the control gain of this

Keywords： Hypersonic vehicle     Constraints     Output redefinition     Barrier Lyapunov function    

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Passive convergence-permeable reactive barrier (PC-PRB): An effective configuration to enhance hydraulic

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 12, doi: 10.1007/s11783-022-1591-y

Abstract:

● A novel PRB configuration based on passive convergent flow effect was proposed.

Keywords： Passive convergence-permeable reactive barrier (PC-PRB)     Permeable reactive barrier configuration     Numerical    

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Hydrogen production from methanol through dielectric barrier discharge

Baowei WANG, Xu ZHANG, Haiying BAI, Yijun Lü, Shuanghui HU

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 2,   Pages 209-214 doi: 10.1007/s11705-010-1018-3

Abstract: In this paper, methanol reforming to produce H through dielectric-barrier discharge (DBD) plasma reaction

Keywords： methanol     dielectric-barrier discharge     hydrogen     plasma    

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Calorie restriction and its impact on gut microbial composition and global metabolism

Xiaojiao Zheng, Shouli Wang, Wei Jia

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 634-644 doi: 10.1007/s11684-018-0670-8

Abstract: In the present review, we focus on the general effect of CR on gut microbiota composition and globalAnalyses of the gut microbial and host metabolisms revealed that most host microbial co-metabolites wereThe observed phenotypes and the further verification of the direct link between gut microbiota and metabolomeThus, improved gut microbiota composition and metabolome are potential biomarkers for determining the

Keywords： caloric restriction     gut microbiota     metabolome    

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Numerical modeling and performance evaluation of passive convergence-permeable reactive barrier (PC-PRB

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 11, doi: 10.1007/s11783-023-1731-z

Abstract:

● A 2D finite-element solute transport model, PRB-Trans, is developed.

Keywords： Passive convergence-permeable reactive barrier     Numerical modeling     Hydraulic behavior assessment     Pollutant    

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Degradation of metronidazole by dielectric barrier discharge in an aqueous solution

Zhipeng Yang, Anxing Lai, Hangyu Chen, Youxiang Yan, Ye Yang, Weiwei Zhang, Lei Wang

Frontiers of Environmental Science & Engineering 2019, Volume 13, Issue 3, doi: 10.1007/s11783-019-1117-4

Abstract:

The discharge characteristics during the degradation of MNZ by DBD were investigated.

Increasing the discharge frequency can promote the degradation of MNZ.

MNZ removal reaches 99.1% at the initial concentration of 40 ppm within 120 min.

Coexisting organic matter inhibits the degradation of MNZ.

The energy efficiency of DBD for MNZ removal is higher than other technologies.

Keywords： Dielectric barrier discharge     Antibiotic     Metronidazole     Water treatment    

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From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 191-200 doi: 10.1007/s11684-013-0258-2

Abstract:

Increasing evidence suggests that the gut may influence the host’s metabolism and ultimatelyWe review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgery, and discuss the potential mechanisms underlying the above relationship: gut anatomical rearrangement, microbial composition changes, altered gut cells, and gut hormone modulation.

Keywords： gastric bypass     T2DM     gut    

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Dielectric barrier micro-plasma reactor with segmented outer electrode for decomposition of pure CO

Baowei Wang, Xiaoxi Wang, Bo Zhang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3,   Pages 687-697 doi: 10.1007/s11705-020-1974-1

Abstract: Four coaxial cylinder dielectric barrier discharge micro-plasma reactors were designed for the non-catalyticCompared with other types of dielectric barrier discharge plasma reactors, the proposed segmented outer

Keywords： CO2 decomposition     dielectric barrier discharge     segmented outer electrodes     electrical analysis    

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Numerical simulations of morphological changes in barrier islands induced by storm surges and waves using

Soumendra Nath KUIRY, Yan DING, Sam S Y WANG

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 1,   Pages 57-68 doi: 10.1007/s11709-014-0235-0

Abstract: presented for simulating supercritical coastal flows and morphological changes in a tidal/coastal inlet and barrierBarrier island breaching, overflow and overwash due to severe storm attack are simulated and the predicted

Keywords： coastal inlet     coastal process modeling     supercritical flow     sediment transport     barrier islands    

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Title Author Date Type Operation

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Journal Article

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Journal Article

Gut microbial balance and liver transplantation: alteration, management, and prediction

Xinyao Tian, Zhe Yang, Fangzhou Luo, Shusen Zheng

Journal Article

Integrated analysis of gut microbiome and host immune responses in COVID-19

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Journal Article

Adaptive tracking control for air-breathing hypersonic vehicles with state constraints

Gong-jun LI

Journal Article

Passive convergence-permeable reactive barrier (PC-PRB): An effective configuration to enhance hydraulic

Journal Article

Hydrogen production from methanol through dielectric barrier discharge

Baowei WANG, Xu ZHANG, Haiying BAI, Yijun Lü, Shuanghui HU

Journal Article

Calorie restriction and its impact on gut microbial composition and global metabolism

Xiaojiao Zheng, Shouli Wang, Wei Jia

Journal Article

Numerical modeling and performance evaluation of passive convergence-permeable reactive barrier (PC-PRB

Journal Article

Degradation of metronidazole by dielectric barrier discharge in an aqueous solution

Zhipeng Yang, Anxing Lai, Hangyu Chen, Youxiang Yan, Ye Yang, Weiwei Zhang, Lei Wang

Journal Article

From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Journal Article

Dielectric barrier micro-plasma reactor with segmented outer electrode for decomposition of pure CO

Baowei Wang, Xiaoxi Wang, Bo Zhang

Journal Article

Numerical simulations of morphological changes in barrier islands induced by storm surges and waves using

Soumendra Nath KUIRY, Yan DING, Sam S Y WANG

Journal Article